Nigerian internationals Akor Adams and Chidera Ejuke played for Sevilla in their 3-1 loss to Mallorca in the Spanish La Liga on Saturday.
Adams came on in the 71st minute, while Ejuke was introduced with just two minutes left in the game.
The defeat leaves Sevilla in seventh place with 13 points in the league table.
A win against Mallorca would have taken Sevilla five points behind leaders Real Madrid.
Sevilla had previously won two straight games, including a 4-1 win against Barcelona.
It looked as if Sevilla would continue their impressive run when they took the lead in the 16th minute through Vargas.
Author's summary: Sevilla lost to Mallorca despite lead.